40 research outputs found

    Apparatus for a Search for T-violating Muon Polarization in Stopped-Kaon Decays

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    The detector built at KEK to search for T-violating transverse muon polarization in K+ --> pi0 mu+ nu (Kmu3) decay of stopped kaons is described. Sensitivity to the transverse polarization component is obtained from reconstruction of the decay plane by tracking the mu+ through a toroidal spectrometer and detecting the pi0 in a segmented CsI(Tl) photon calorimeter. The muon polarization was obtained from the decay positron asymmetry of muons stopped in a polarimeter. The detector included features which minimized systematic errors while maintaining high acceptance.Comment: 56 pages, 30 figures, submitted to NI

    Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

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    BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

    A Biofunctional Fibrous Scaffold for the Encapsulation of Human Mesenchymal Stem Cells and its Effects on Stem Cell Differentiation

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    10.1007/978-3-540-92841-6_314IFMBE Proceedings231279-128

    Hierarchical planning for self-reconfiguring robots using module kinematics

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    Reconfiguration allows a self-reconfiguring modular robot to adapt to its environment. The reconfiguration planning problem is one of the key algorithmic challenges in realizing self-reconfiguration. Many existing successful approaches rely on grouping modules together to act as meta-modules. However, we are interested in reconfiguration planning that does not impose fixed meta-module relationships but instead forms cooperative relationships between modules dynamically. This approach avoids the need to hand-code meta-module motions and potentially allows reconfiguration with fewer modules. In this paper we present a general two level reconfiguration framework. The top level plans in module-connector space using distributed dynamic programming. The lower level accepts a transition function for the kinematic model of the chosen module type as input. As an example, we implement such a transition function for the 3R, SuperBot-style module. Although not explored in this paper, this general approach is naturally extended to consider power use, clock time, or other quantities of interest. © 2013 Springer-Verlag
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